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. 2019 Apr 18;9:6272. doi: 10.1038/s41598-019-42738-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The influence of DOAC on WM-266-4 tumour invasion. Tumour spheroids were prepared by seeding out WM-266-4 (2 × 10⁴) in non-adherent Nunclon Sphera 96 wells plates in 50 µl of media. After 4 days the tumours were transferred to Cultrex Spheroid Invasion matrix in 12-well µ-chambers and supplemented with the appropriate media (100 µl) containing a range of concentrations of Apixaban (0–1 µg/ml) or Rivaroxaban (0–0.6 µg/ml). (A) The spheroid tumours were examined daily for up to 3 days, by white-light microscopy and photographed. (B) The invasion of the cells into the matrix was analysed using ImageJ software. (n = 3).