Table 1.

List of selected calcium channel blockers

Drugs	Class	Suggested primary target	Plasma half-life (human)	Crosses BBB
Nimodipine	Dihydropyridine	L-Type channel P/Q channel	1.7–9 h	Yes
Isradipine	Dihydropyridine	L-Type channel	8 h	Yes
Felodipine	Dihydropyridine	L-Type channel T-Type channel	8.5–19.7 h	Yes
Verapamil	Non-dihydropyridine (phenylalkylamine)	L-Type channel B-Type channel P/Q channel	2.8–7.4 h	No
Diltiazem	Non-dihydropyridine (benzothiazepine)	L-Type channel	3–4.5 h	Poor
Amlodipine	Dihydropyridine	L-Type channel	30–50 h	No
Nifedipine	Dihydropyridine	L-Type channel	2–7 ha	Yes
Nicardipine	Dihydropyridine	L-Type channel	8.6 h	Yes
Clevidipine	Dihydropyridine	L-Type channel	1 min	Yes
			(2–15 min)
Nisoldipine	Dihydropyridine	L-Type channel	7–12 h	Yes

The primary target human plasma half-life and BBB penetration information was obtained from PubChem (https://pubchem.ncbi.nlm.nih.gov/) and DrugBank (https://www.drugbank.ca/), accurate at the time of manuscript submission

^a7 h half-life determined from slow release formulation