Table 2.
PK parameters of felodipine in mice
| PK parameter | Units | Plasma | Brain |
|---|---|---|---|
| C max | ng/mL | 1151 | 3500 |
| t max | hours | 1 | 1 |
| t 1/2 | hours | 0.9 | 1.8 |
| T1 | hours | 1 | 1 |
| T2 | hours | 4 | 8 |
| AUC0-t | ng.h/ml | 2406 | 8776 |
| AUC0-∞ | ng.h/ml | 2540 | 9330 |
PK analysis was performed after single dose of 5 mg/kg body weight via i.p. injection. The PK parameters were calculated from the mean values from 3 mice at each time-point. Hence, these PK parameters have no SDs. SDs would not be appropriate, since the values at each time-point are from different mice. The spread of concentrations in the mice at each time-point is given in the analytical data (Table 3)