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Felodipine plasma and brain concentration in mice after single i.p. injection
| Time (min) | Plasma (ng/ml) | Brain (ng/g) | Brain:plasma ratio |
|---|---|---|---|
| 5 | 710.7 ± 105.0 | 1208.0 ± 760.8 | 2 |
| 15 | 957.7 ± 210.9 | 1738.3 ± 498.3 | 2 |
| 60 | 1151.0 ± 415.5 | 3500.0 ± 649.0 | 3 |
| 120 | 511.3 ± 260.9 | 1886.7 ± 373.5 | 4 |
| 240 | 105.5 ± 27.0 | 501.0 ± 314.6 | 5 |
| 480 | 106.7 ± 17.5 | 216.4 ± 107.6 | 2 |
Analysis was performed after single dose of 5 mg/kg body weight via i.p. injection (n = 3 mice per time-point). Data are presented as mean values ± SEM
