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. 2019 Apr 18;9:6282. doi: 10.1038/s41598-019-42788-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Prevalence of Abs against HERV_Env antigens in Sardinian rT1D children (A), rT1D youths from mainland Italy (B) and Polish T1D youths (C) along with the respective control groups. The dotted lines represent positivity thresholds calculated by ROC analysis. Dashed lines indicate the respective mean AU/ml values. Area under the curve (AUC) and statistical significance, when attained, are reported for each distribution.