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. 2019 Apr 18;9:6282. doi: 10.1038/s41598-019-42788-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-related seroreactivity against HERV-W_Env and homologous MAP/human antigens in subjects at T1D risk from Sardinia (A) and mainland Italy (B). For graphical simplification, data relative to MAP/ZnT8 or MAP/PI sets are represented as separated means since values obtained for each of the four peptides included in their specific set fell into similar ranges. Results shown correspond to subjects for which at least 4 follow-up samples were available with patients’ identifiers reported above the Y axis of each graph. HERV-W_Env: continuous line. MAP/PI: dashed line. MAP/ZnT8: dotted line. m: months. y: years.