Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 18;10:1812. doi: 10.1038/s41467-019-09734-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — AURKB and pH3 in PC9-derived cell lines resistant to EGFR TKIs. a Levels of AURKB mRNA in the cells of the panel. Values shown are means ± SD of three independent determinations (n = 3). b Levels of AURKB by ICC in the parental PC9 and the resistant lines PC9-ER (p.T790M negative) and PC9-GR4 (p.T790M positive). Scale bars indicate 10 μm. c Levels of AURKB in the parental PC9 and the cell lines resistant to first generation EGFR TKIs by western blotting. d Levels of histone H3 and pH3 in the same cell lines by western blotting. e–g IHC of pH3 (e), Ki67 (f) and H-score of Ki67, mitotic pH3 and non-mitotic pH3 (g) in the 12 cell lines resistant to EGFR TKIs. Scale bars indicate 50 μm. Values shown are means of two blind determinations performed independently by two expert pathologists (n = 2)