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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Angiogenesis. 2018 Jul 3;21(4):677–698. doi: 10.1007/s10456-018-9629-2

Figure 8. Vegfr3Luc reporter mice for whole-body analysis of benign and malignant melanocytic lesions.

Figure 8.

(a) Five strains of Vegfr3Luc mice generated. (b) Xenografts of mCherry–SK-Mel-147 cells, imaged as indicated. (c) Confocal immunomicroscopy of VEGFR3 (red) and Lyve1 (green) in normal skin or xenografts of SK -Mel-147 cells. (d) Four main patterns (I–IV) of V3-Luc emission identified by whole-body bioluminescence of mice bearing xenografts of the indicated melanoma cell lines. Numbers represent days after implantation and dotted lines show tumor area. (e) V3-Luc emission at the indicated locations and tumor volumes. LN, lymph nodes. Data are mean ± s.d. Fluorescence: p s−1 cm−2 sr−1 × 109; bioluminescence: p s−1 cm−2 per sr × 106. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Reprinted with permission from [47].