Table 1.

Promoter genes used in generating transgenic mouse lines with inherently fluorescent blood endothelial cells.

	Marker	Mouse line	Fluorescent Protein	First author	Year	Title/Reference
Blood endothelial cells	Flk1	Tg(Flk1::myr-mCherry)	mCherry	Larina	2009	A membrane-associated mCherry fluorescent reporter line for studying vascular remodeling and cardiac function during murine embryonic development [28].
	Flk1	Tg(Flk1::H2B-EYFP)	EYFP	Fraser	2005	Using a histone yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice [29].
	Flk1	Flk1+/EGFP mice	GFP	Ema	2006	Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors; [30].
	Flk1	Flk1-GFP BAC Tg mice	GFP	Ishitobi	2010	Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development [31].
	Flt1	Flk1-tdsRed BAC Tg mice	tdsRed	Matsumoto	2012	Study of normal and pathological blood vessel morphogenesis in Flt1-tdsRed BAC Tg mice[26].
	Flk1	Flk1-Nano-lantern BAC tg mice	Nano-lantern	Matsushita	2017	Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice [27].
	Flt1	Flt‐1/eGFP‐anillin	eGFP-anillin	Herz	2018	Visualization of endothelial cell cycle dynamics in mouse using the Flt‐1/eGFP‐anillin system [32].
	Tie2	Tie2-GFP	GFP	Motoike	2000	Universal GFP reporter for the study of vascular development [33].
	Tie2	Tie2-GFP	GFP	Glaser	2014	Specialized mouse embryonic stem cells for studying vascular development [34].
	Tie1	Tie1-GFP	GFP	Iljin	2002	A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos [35].
	Ephrin B2	Ephrin-B2-H2BGFP	GFP	Davy	2006	Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome [36].
	Claudin5	Tg eGFP-claudin5 (fusion protein)	GFP	Knowland	2014	Stepwise recruitment of transcellular and paracellular pathways underlies blood–brain barrier breakdown in stroke [37].
	VE-cadherin	VE-cadherin-EGFP	EGFP	Winderlich	2009	VE-PTP controls blood vessel development by balancing Tie-2 activity [38].