Table 4:
Tissue remodeling, Signaling, Cell Migration and Proliferation
| Protease/Inhibitor | Uniprot | Action |
|---|---|---|
| ADAM family (a disintegrin and metalloprotease) | Play roles in fertilization, proliferation, migration and cell adhesion | |
| Not all are proteases, those which are act as sheddases | ||
| ADAM-TS (a disintegrin and metalloproteinase with thrombospondin motifs | Process procollagen and von Willebrand factor, and cleave extracellular matrix aggrecan, versican, brevican and neurocan | |
| MMPs (Matrix metalloproteinases ) | All implicated in metastasis except 12, 20, and 28 | |
| TIMPs (tissue-inhibitors of metalloproteinases ) | Endogenous inhibitors of MMPs | |
| MMP-1 | P03956 | Cleaves collagens I, II, III, VII, and X |
| Mediates neurotoxicity of HIV viral Tat protein | ||
| MMP-8 | P22894 | Degrades fibrillar collagens I, II, and III |
| MMP-13 | P45452 | Cleaves collagens I, II, III, IV, XIV, and X |
| Degrades fibrillar collagen, fibronectin, tenascin C, and aggrecan | ||
| MMP-2 | P08253 | Degrades extracellular matrix proteins, including collagen I and IV |
| MMP-9 | P14780 | Cleaves collagen IV and V and fibronectin |
| Implicated in neovascularization in malignant gliomas | ||
| MMP-3 | P08254 | Degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans |
| Activates MMPs 1, 7, and 9 | ||
| MMP-10 | P09238 | Degrades fibronectin, gelatins of type I, III, IV, and V, collagens III, IV, and V |
| Activates procollagenase | ||
| MMP-11 | P24347 | Cleaves alpha 1-proteinase inhibitor, activated intracellularly by furin |
| MMP-7 | P09237 | Degrades casein, gelatins of types I, III, IV, and V, and fibronectin |
| Activates procollagenase | ||
| Activates MMP2 and MMP9 | ||
| MMP-12 | P39900 | Cleaves elastin, implicated in aneurysm formation |
| MMP-20 | O60882 | Degrades amelogenin, aggrecan, and cartilage oligomeric matrix protein (COMP) |
| MMP-26 | Q9NRE1 | Degrades collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor |
| Activates progelatinase B | ||
| MMP-28 | Q9H239 | Degrades casein |
Tissue Remodeling, Signaling, Cell Migration, and Proliferation: Activities and uniprot ID codes (where applicable) of proteases, protease inhibitors, and cofactors associated with tissue remodeling, signaling, cell migration, and proliferation.