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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Methods Mol Biol. 2019;1871:313–392. doi: 10.1007/978-1-4939-8814-3_20

Table 6:

Protein Secretion

Protease/Inhibitor Uniprot Action
Signal Peptidase Removes amino terminal signal sequences from secretory pro-proteins
Group of aspartic proteases
Insulin P01308 increases cell permeability to monosaccharides, amino acids and fatty acids
accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Calcitonin P01258 Promotes rapid incorporation of calcium and phosphate into bone
Atrial natriuretic peptide (ANP) P01160 Peptide hormone
regulates of natriuresis, diuresis, and vasodilation
promotes trophoblast invasion and spiral artery remodeling in uterus during pregnancy
Binds and stimulates the cGMP production of the NPR1 receptor
Binds the clearance receptor NPR3
Brain natriuretic peptide (BNP) P16860 Peptide hormone
Regulates natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion
Binds and stimulates the cGMP production of the NPR1 receptor
Binds the clearance receptor NPR3
Natriuretic peptide precursor C (NPPC) P23582 Peptide hormone
Regulates of cartilaginous growth plate chondrocytes proliferation and differentiation
Binds and stimulates the cGMP production of the NPR2 receptor

Protein Secretion: Activities and uniprot ID codes (where applicable) of proteases, protease inhibitors, and cofactors associated with protein secretion.