3.

TSA of the effect of haemostatic transfusion guided by TEG or ROTEM on proportion of patients in need of FFP resulted in a TSA alfa‐spending boundary adjusted RR of 0.6 (95% CI 0.55 to 0.65) with the cumulative Z‐curve crossing the boundary constructed for an information size of 372 in the meta‐analysis with a RRR of 40% (alfa = 0.05) and a power of 80% (beta = 0.20) in a random‐effects model with high heterogeneity (I² = 73%) and diversity (D²= 88%) and control group event rate of 47.1% with continuity adjustment for zero event trials (0.001 in each arm). However, one has to exert caution when interpreting indications of firm evidence for this outcome, since only two trials had low risk of bias (Nakayama 2015; Shore‐Lesserson 1999) and the required information size based on these two trials is 2921 and the cumulative Z‐curve does not cross the boundary.