Kultufan Turan 2006.

Methods	Two‐group parallel RCT, one centre ITT: unclear Funding: not for profit Overall study quality: high risk of bias No sample size calculation was reported
Participants	Inclusion criteria: Cardiac surgery either CABG or valve surgery Exclusion criteria: None stated
Interventions	Intervention group: TEG‐guided transfusion algorithm group for intervention after open heart surgery Transfusion algorithm was fully based on TEG (ROTEG), (n = 20) Control group: routine transfusion therapy for intervention after cardiopulmonary bypass, standard laboratory coagulation testing, (n = 20) Duration of intervention: peri‐ and postoperative algorithm. Postoperative transfusion was indicated if bleeding was > 400 mL within an hour or > 1000 mL within 4 hours. ROTEG was performed perioperatively and 1 hour postoperation
Outcomes	Primary: incidence of blood transfusion (whole blood, RBCs, FFP, and platelets) Secondary: unclear. No data on adverse events
Notes	Country: Turkey. Language: Turkish Letter sent to authors in April and June 2010. Reply and supplemental data received in April and June 2010 Follow‐up: 24 hours. Authors conclusion:"We conclude that utilization of ROTEG does not alter the transfusion management significantly in open heart surgery"
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Unclear.
Allocation concealment (selection bias)	Unclear risk	Unclear.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	The doctor in charge of performing the ROTEG and the medical doctor in the ICU were blinded. However, it is unclear if the anaesthesiologist in charge of transfusion perioperatively were blinded to the group allocation.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Unclear.
Selective reporting (reporting bias)	Low risk	Yes. Unable to compare with protocol or trial registration but appears to be free of selective reporting.
Other bias	Low risk	Appears adequate and free of other biases.