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. 2016 Oct 31;2016(10):CD010683. doi: 10.1002/14651858.CD010683.pub3

Comparison 5. Methods of dealing with cut surface.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Mortality (perioperative) 10   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 Fibrin sealant vs control 2 380 Odds Ratio (M‐H, Fixed, 95% CI) 3.56 [0.73, 17.35]
1.2 Fibrin sealant and collagen vs control 1 300 Odds Ratio (M‐H, Fixed, 95% CI) 3.08 [0.61, 15.53]
1.3 Fibrin sealant vs argon beam 2 227 Odds Ratio (M‐H, Fixed, 95% CI) 1.37 [0.46, 4.03]
1.4 Fibrin sealant vs collagen 3 256 Odds Ratio (M‐H, Fixed, 95% CI) 0.90 [0.24, 3.32]
1.5 Oxidised cellulose vs fibrin sealant 1 50 Odds Ratio (M‐H, Fixed, 95% CI) 0.55 [0.03, 9.33]
1.6 Plasmajet vs fibrin sealant 1 58 Odds Ratio (M‐H, Fixed, 95% CI) 0.64 [0.10, 4.16]
2 Serious adverse events (proportion) 7   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Fibrin sealant vs control 3 457 Odds Ratio (M‐H, Fixed, 95% CI) 1.03 [0.64, 1.65]
2.2 Fibrin sealant vs argon beam 1 106 Odds Ratio (M‐H, Fixed, 95% CI) 0.62 [0.25, 1.55]
2.3 Fibrin sealant vs collagen 1 127 Odds Ratio (M‐H, Fixed, 95% CI) 1.57 [0.73, 3.38]
2.4 Oxidised cellulose vs fibrin sealant 1 50 Odds Ratio (M‐H, Fixed, 95% CI) 0.57 [0.17, 1.87]
2.5 Plasmajet vs fibrin sealant 1 58 Odds Ratio (M‐H, Fixed, 95% CI) 0.14 [0.02, 1.22]
3 Serious adverse events (number) 6   Rate Ratio (Fixed, 95% CI) Subtotals only
3.1 Fibrin sealant vs control 1 70 Rate Ratio (Fixed, 95% CI) 0.94 [0.48, 1.86]
3.2 Fibrin sealant and collagen vs control 1 300 Rate Ratio (Fixed, 95% CI) 1.32 [0.76, 2.29]
3.3 Fibrin sealant vs argon beam 1 121 Rate Ratio (Fixed, 95% CI) 4.47 [1.50, 13.27]
3.4 Fibrin sealant vs collagen 2 189 Rate Ratio (Fixed, 95% CI) 1.22 [0.76, 1.98]
3.5 Fibrin sealant vs cyanoacrylate 1 30 Rate Ratio (Fixed, 95% CI) 1.0 [0.06, 15.99]
3.6 Oxidised cellulose vs cyanoacrylate 1 30 Rate Ratio (Fixed, 95% CI) 4.00 [0.45, 35.79]
3.7 Oxidised cellulose vs fibrin sealant 1 30 Rate Ratio (Fixed, 95% CI) 4.00 [0.45, 35.79]
4 Adverse events (proportion) 9   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Fibrin sealant versus control 3 457 Odds Ratio (M‐H, Fixed, 95% CI) 0.80 [0.55, 1.17]
4.2 Fibrin sealant and collagen vs control 1 300 Odds Ratio (M‐H, Fixed, 95% CI) 1.0 [0.59, 1.71]
4.3 Fibrin sealant vs argon beam 2 227 Odds Ratio (M‐H, Fixed, 95% CI) 0.97 [0.58, 1.64]
4.4 Fibrin sealant vs collagen 1 127 Odds Ratio (M‐H, Fixed, 95% CI) 0.95 [0.46, 1.93]
4.5 Oxidised cellulose vs fibrin sealant 2 274 Odds Ratio (M‐H, Fixed, 95% CI) 0.77 [0.30, 2.01]
5 Adverse events (number) 5   Rate Ratio (Fixed, 95% CI) Subtotals only
5.1 Fibrin sealant vs control 1 70 Rate Ratio (Fixed, 95% CI) 1.01 [0.75, 1.36]
5.2 Fibrin sealant vs argon beam 1 121 Rate Ratio (Fixed, 95% CI) 1.12 [0.75, 1.66]
5.3 Fibrin sealant vs collagen 2 189 Rate Ratio (Fixed, 95% CI) 1.13 [0.90, 1.42]
5.4 Fibrin sealant vs cyanoacrylate 1 30 Rate Ratio (Fixed, 95% CI) 1.50 [0.25, 8.98]
5.5 Oxidised cellulose vs cyanoacrylate 1 30 Rate Ratio (Fixed, 95% CI) 3.50 [0.73, 16.85]
5.6 Oxidised cellulose vs fibrin sealant 1 30 Rate Ratio (Fixed, 95% CI) 2.33 [0.60, 9.02]
6 Blood transfusion (proportion) 4   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
6.1 Fibrin sealant vs control 2 392 Odds Ratio (M‐H, Fixed, 95% CI) 1.04 [0.61, 1.76]
6.2 Fibrin sealant and collagen vs control 1 300 Odds Ratio (M‐H, Fixed, 95% CI) 1.52 [0.88, 2.61]
6.3 Fibrin sealant vs cyanoacrylate 1 30 Odds Ratio (M‐H, Fixed, 95% CI) 3.25 [0.52, 20.37]
6.4 Oxidised cellulose vs cyanoacrylate 1 30 Odds Ratio (M‐H, Fixed, 95% CI) 2.36 [0.36, 15.45]
6.5 Oxidised cellulose vs fibrin sealant 1 30 Odds Ratio (M‐H, Fixed, 95% CI) 0.73 [0.15, 3.49]
7 Blood transfusion (red blood cell) 5   Mean Difference (IV, Random, 95% CI) Subtotals only
7.1 Fibrin sealant vs control 2 122 Mean Difference (IV, Random, 95% CI) ‐0.53 [‐1.00, ‐0.06]
7.2 Fibrin sealant and collagen vs control 1 300 Mean Difference (IV, Random, 95% CI) ‐0.01 [‐0.16, 0.14]
7.3 Fibrin sealant vs collagen 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7.4 Fibrin sealant vs cyanoacrylate 1 30 Mean Difference (IV, Random, 95% CI) 2.2 [1.59, 2.81]
7.5 Oxidised cellulose vs cyanoacrylate 1 30 Mean Difference (IV, Random, 95% CI) ‐0.27 [‐0.81, 0.27]
7.6 Oxidised cellulose vs fibrin sealant 2 80 Mean Difference (IV, Random, 95% CI) ‐1.76 [‐2.00, 0.47]
8 Blood transfusion (fresh frozen plasma) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
8.1 Fibrin sealant vs cyanoacrylate 1 30 Mean Difference (IV, Fixed, 95% CI) ‐0.8 [‐1.01, ‐0.59]
8.2 Oxidised cellulose vs cyanoacrylate 1 30 Mean Difference (IV, Fixed, 95% CI) ‐0.27 [‐0.55, 0.01]
8.3 Oxidised cellulose vs fibrin sealant 2 80 Mean Difference (IV, Fixed, 95% CI) 0.53 [0.35, 0.71]
9 Blood loss 5   Mean Difference (IV, Fixed, 95% CI) Subtotals only
9.1 Fibrin sealant vs control 2 350 Mean Difference (IV, Fixed, 95% CI) 0.10 [‐0.13, 0.33]
9.2 Fibrin sealant and collagen vs control 1 300 Mean Difference (IV, Fixed, 95% CI) 0.06 [‐0.06, 0.19]
9.3 Fibrin sealant vs collagen 1 62 Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.54, 0.68]
9.4 Fibrin sealant vs cyanoacrylate 1 30 Mean Difference (IV, Fixed, 95% CI) 0.11 [‐0.20, 0.43]
9.5 Oxidised cellulose vs cyanoacrylate 1 30 Mean Difference (IV, Fixed, 95% CI) ‐0.08 [‐0.35, 0.19]
9.6 Oxidised cellulose vs fibrin sealant 1 30 Mean Difference (IV, Fixed, 95% CI) ‐0.19 [‐0.45, 0.06]
10 Total hospital stay 4   Mean Difference (IV, Fixed, 95% CI) Subtotals only
10.1 Fibrin sealant vs control 1 82 Mean Difference (IV, Fixed, 95% CI) ‐0.5 [‐2.45, 1.45]
10.2 Fibrin sealant and collagen vs control 1 300 Mean Difference (IV, Fixed, 95% CI) 0.70 [‐1.83, 3.23]
10.3 Fibrin sealant vs cyanoacrylate 1 30 Mean Difference (IV, Fixed, 95% CI) ‐1.34 [‐3.61, 0.93]
10.4 Oxidised cellulose vs cyanoacrylate 1 30 Mean Difference (IV, Fixed, 95% CI) ‐0.67 [‐3.12, 1.78]
10.5 Oxidised cellulose vs fibrin sealant 2 80 Mean Difference (IV, Fixed, 95% CI) 0.25 [‐1.84, 2.33]
11 ITU stay 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
11.1 Oxidised cellulose vs fibrin sealant 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12 Operating time 5   Mean Difference (IV, Fixed, 95% CI) Subtotals only
12.1 Fibrin sealant vs control 2 122 Mean Difference (IV, Fixed, 95% CI) ‐14.55 [‐52.86, 23.76]
12.2 Fibrin sealant and collagen vs control 1 300 Mean Difference (IV, Fixed, 95% CI) 19.0 [2.09, 35.91]
12.3 Fibrin sealant vs collagen 1 62 Mean Difference (IV, Fixed, 95% CI) ‐4.0 [‐44.33, 36.33]
12.4 Oxidised cellulose vs fibrin sealant 1 50 Mean Difference (IV, Fixed, 95% CI) 5.40 [‐70.13, 80.93]