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. 2016 Oct 31;2016(10):CD010683. doi: 10.1002/14651858.CD010683.pub3

Doklestic 2012.

Methods Randomised clinical trial
Participants Country: Serbia
 Number randomised: 60
 Postrandomisation dropouts: not stated
 Revised sample size: 60
 Average age: 58 years
 Women: 40 (66.7%)
 Number of cirrhotics: 0 (0%)
 Number of major liver resections: 20 (51.6%)
 Number of right hepatectomies: not stated
 Follow‐up (months): 1
 Further details of methods of liver resection

  1. Vascular occlusion: intermittent portal triad clamping

  2. Parenchymal transection: factor being randomised

  3. Fibrin glue: not stated

  4. Pharmacological methods: not stated

  5. Cardiopulmonary methods: low central venous pressure

  6. Autologous transfusion: not stated


Inclusion criteria: 
 patients undergoing hepatectomy for benign or malignant tumours in patients with adequate functional reserve of the heart, lungs, and kidneys
 Exclusion criteria: 
 cirrhosis
Interventions Participants were randomly assigned to 3 groups.
 Group 1: clamp‐crush method (n = 20)
 Group 2: cavitron ultrasonic surgical aspirator (n = 20)
 Group 3: radiofrequency dissecting sealer (LIGASURE) (n = 20)
Outcomes The outcomes reported were: short‐term mortality, proportion of people with serious adverse events, proportion of people with any adverse events, operative blood loss, proportion of people requiring blood transfusion, length of hospital stay, length of intensive therapy unit stay, and operating time.
Notes —
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: this information was not available.
Allocation concealment (selection bias) Unclear risk Quote: "The randomization was performed on the day prior to surgery using the sealed envelopes; each group consisted of 20 subjects".
 Comment: further details of sealed envelope method were not available.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: this information was not available.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: this information was not available.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: this information was not available.
Selective reporting (reporting bias) Low risk Comment: mortality and morbidity were reported.
Vested interest bias Low risk Quote: "This study was supported by funding by funding from the Ministry of Education and Science of the Republic of Serbia".
Other bias Low risk Comment: no other bias