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. 2016 Oct 31;2016(10):CD010683. doi: 10.1002/14651858.CD010683.pub3

Kostopanagiotou 2007.

Methods Randomised clinical trial
Participants Country: Greece
 Number randomised: 35
 Postrandomisation dropouts: 7 (20%)
 Revised sample size: 28
 Average age: 52 years
 Women: 11 (39.3%)
 Number of cirrhotics: 0 (0%)
 Number of major liver resections: 16 (57.1%)
 Number of right hepatectomies: 11 (39.3%)
 Follow‐up (months): 12
 Further details of methods of liver resection
  1. Vascular occlusion: hepatic vascular exclusion

  2. Parenchymal transection: not stated

  3. Fibrin glue: not stated

  4. Pharmacological methods: not stated

  5. Cardiopulmonary methods: not stated

  6. Autologous transfusion: factor being randomised


Inclusion criteria
  1. Non‐cirrhotic patients undergoing elective liver resections

  2. ASA II or III


Exclusion criteria: receiving immunosuppressive drugs
Interventions Participants were randomly assigned to 2 groups.
 Group 1: autologous blood donation (n = 15)
 Group 2: control (n = 13)
 Autologous blood donation: 2 units of blood were withdrawn before surgery
Outcomes The outcomes reported were: short‐term mortality, long‐term mortality, proportion of people with any adverse events, operative blood loss, quantity of blood transfused (red cell transfusion or whole blood), length of hospital stay, and operating time.
Notes Reasons for postrandomisation dropouts: requirement of allogenic transfusion in autologous group or did not require any transfusion (4 in intervention group and 3 in control group)
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: this information was not available.
Allocation concealment (selection bias) Unclear risk Comment: this information was not available.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: this information was not available.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: this information was not available.
Incomplete outcome data (attrition bias) 
 All outcomes High risk Comment: there were postrandomisation dropouts.
Selective reporting (reporting bias) High risk Comment: severity of morbidity was not reported.
Vested interest bias Unclear risk Comment: this information was not available.
Other bias Low risk Comment: no other bias