Skip to main content
. 2016 Oct 31;2016(10):CD010683. doi: 10.1002/14651858.CD010683.pub3

Si‐Yuan 2014.

Methods Randomised clinical trial
Participants Country: China
 Number randomised: 160
 Postrandomisation dropouts: 0 (0%)
 Revised sample size: 160
 Average age: 49 years
 Women: 36 (22.5%)
 Number of cirrhotics: 98 (61.3%)
 Number of major liver resections: 112 (70%)
 Number of right hepatectomies: 53 (33.1%)
 Follow‐up (months): until discharge
 Further details of methods of liver resection
  1. Vascular occlusion: factor being randomised

  2. Parenchymal transection: not stated

  3. Fibrin glue: not stated

  4. Pharmacological methods: not stated

  5. Cardiopulmonary methods: low central venous pressure

  6. Autologous transfusion: not stated


Inclusion criteria
  1. Patients who were surgically fit to receive partial hepatectomy

  2. Resectable tumour which had invaded one or more major hepatic vein or was adjacent to the hepatocaval junction

  3. No other concomitant major surgical procedures such as bowel or bile duct resection

  4. No tumour invasion of IVC

  5. Child‐Pugh class A or B

  6. Patient aged between 16 and 65 years

Interventions Participants were randomly assigned to 2 groups.
 Group 1: continuous portal triad clamping (n = 80)
 Group 2: continuous selective hepatic vascular exclusion (n = 80)
Outcomes The outcomes reported were: short‐term mortality, proportion of people with serious adverse events, proportion of people with any adverse events, operative blood loss, proportion of people with major blood loss, proportion of people requiring blood transfusion, quantity of blood transfused (red cell transfusion or whole blood), length of hospital stay, length of intensive therapy unit stay, operating time.
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: this information was not available.
Allocation concealment (selection bias) Low risk Quote: "All eligible patients were randomly assigned to the Pringle manoeuvre and selective hepatic vascular occlusion group by drawing sealed, consecutively numbered, and opaque envelopes after abdominal exploration had confirmed resectability".
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: this information was not available.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: this information was not available.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: there were no postrandomisation dropouts.
Selective reporting (reporting bias) High risk Comment: severity of morbidity was not reported.
Vested interest bias Unclear risk Comment: this information was not available.
Other bias Low risk Comment: no other bias