Fig. 4.

Gene expression analysis and classification of tumour cores. (A) Tumour core ranking based on expression-derived scores arbitrarily generated using normalised RNA sequencing values for all the genes included in the OncotypeDX, Prolaris, and Decipher prognostic signatures. AR activity and percentage genomic aberration (PGA) scores were also calculated and included in the analysis. (B) Unsupervised clustering of tumour cores using gene expression data for the specified signature genes. Cores are colour-coded according to Figure 1.