Fig. 5.

Methylation analysis of prostate specimens from cases 1–6. Tissue types from each individual are colour coded as green (benign) and red (tumour). (A) Unsupervised hierarchical clustering of methylation patterns for tumour and benign cores from cases 1–6. Rows of the heatmaps display the β values for the top 5000 CpG sites with the greatest intrapatient DNA methylation variability. Blue indicates low and yellow represents high methylation level (from 0 to 1). (B) Methylation array–derived β values for APC, GSTP1, and RASSF1 in benign and tumour cores.