Trial	Intervention(s) and comparator(s)	Participants included in analysis (N)	Participants discontinuing trial due to an adverse event (N)	Participants discontinuing trial due to an adverse event (%)	Participants with at least one hospitalisation (N)	Participants with at least one hospitalisation (%)	Participants with at least one outpatient treatment (N)	Participants with at least one outpatient treatment (%)
Atabek 2008	I: metformin + diet and physical activity advice	90	0	0	0	0	0	0
	C: placebo + diet and physical activity advice	30	0	0	0	0	0	0
Berkowitz 2003	I: behavioural programme + sibutramine	42	0	0	‐	‐	‐	‐
	C: behavioural programme + placebo	39	1	2.5	‐	‐	‐	‐
Berkowitz 2006	I: behavioural therapy programme + sibutramine	368	23	6	‐	‐	‐	‐
	C: behavioural therapy programme + placebo	130	7	5	‐	‐	‐	‐
Chanoine 2005	I: orlistat + diet + exercise + behavioural therapy	352	12	3	10	2.8	0	0
	C: placebo + diet + exercise + behavioural therapy	181	3	2	5	2.8	0	0
Clarson 2009	I: metformin + lifestyle intervention	14	0	0	0	0	0	0
	C: lifestyle intervention only	17	0	0	0	0	0	0
Franco 2014	I: sibutramine + dietary guidance	63	0	0	0	0	0	0
	C: placebo + dietary guidance	63	0	0	0	0	0	0
Freemark 2001	I: metformin	15	0	0	0	0	0	0
	C: placebo	17	0	0	0	0	0	0
Garcia‐Morales 2006	I: sibutramine + diet + exercise	23	0	0	‐	‐	‐	‐
	C: placebo + diet + exercise	23	0	0	‐	‐	‐	‐
Godoy‐Matos 2005	I: sibutramine + hypocaloric diet + exercise	30	0	0	0	0	0	0
	C: placebo + hypocaloric diet + exercise	30	0	0	0	0	0	0
Kendall 2013	I: metformin + healthy lifestyle advice	74	0	0	‐	‐	‐	‐
	C: control + healthy lifestyle advice	77	0	0	‐	‐	‐	‐
Maahs 2006	I: orlistat + diet and exercise therapy	20	3	15	‐	‐	‐	‐
	C: placebo + diet and exercise therapy	20	0	0	‐	‐	‐	‐
Mauras 2012	I: metformin + diet/exercise intervention	35	0	0	0	0	0	0
	C: diet/exercise intervention	31	0	0	0	0	0	0
NCT00001723	I: orlistat + behavioural weight loss programme	100	1	1	‐	‐	‐	‐
	C: placebo + behavioural weight loss programme	100	2	2	‐	‐	‐	‐
Ozkan 2004	I: conventional treatment + orlistat	22	7	32	‐	‐	‐	‐
	C: conventional treatment	20	0	0	‐	‐	‐	‐
Prado 2012	I: metformin + nutritional guide and exercise programme	10	0	0	0	0	0	0
	C: placebo + nutritional guide and exercise programme	9	0	0	0	0	0	0
Rezvanian 2010	I1: metformin + healthy eating and physical activity advice	45	0	0	0	0	0	0
	I2: fluoxetine + healthy eating and physical activity advice	45	0	0	0	0	0	0
	I3: metformin and fluoxetine + healthy eating and physical activity advice	45	0	0	0	0	0	0
	C: placebo + healthy eating and physical activity advice	45	0	0	0	0	0	0
Srinivasan 2006	I: metformin first then placebo + "standardised information on healthy eating and exercise"	13	0	0	0	0	0	0
	C: placebo first then metformin + "standardised information on healthy eating and exercise"	15	0	0	0	0	0	0
Van Mil 2007	I: sibutramine + energy‐restricted diet and exercise plan	12	1	8	0	0	0	0
	C: placebo + energy‐restricted diet and exercise plan	12	0	0	0	0	0	0
Wiegand 2010	I: metformin + multiprofessional lifestyle intervention	36	3	8.3	‐	‐	‐	‐
	C: placebo + multiprofessional lifestyle intervention	34	1	2.9	‐	‐	‐	‐
Wilson 2010	I: metformin + lifestyle intervention	38	3	7.9	‐	‐	‐	‐
	C: placebo + lifestyle intervention	38	1	2.6	‐	‐	‐	‐
Yanovski 2011	I: metformin + dietitian‐administered weight‐reduction programme	53	1	1.9	‐	‐	‐	‐
	C: placebo + dietitian‐administered weight‐reduction programme	47	0	0	‐	‐	‐	‐
"‐" denotes not reported. C: comparator; I: intervention; n: number of participants.