| Study | Reason for exclusion |
|---|---|
| Andelman 1967 | Duration of treatment only 11 weeks |
| Ardizzi 1996 | Duration of drug treatment only 2 months |
| Arman 2008 | Treatment of schizophrenia or schizoaffective disorder |
| Bacon 1967 | Duration of treatment only 2 months |
| Beyer 1980 | Adults |
| Burgert 2008 | Duration of follow‐up < 6 months |
| Canlorbe 1976 | Duration of follow‐up only 12 weeks |
| Cannella 1968 | Adults |
| Casteels 2010 | Children had neurogenic or myogenic motor deficit |
| Cayir 2015 | Not an RCT |
| CTRI/2011/10/002081 2011 | Duration of follow‐up < 6 months |
| Danielsson 2007 | Aim was to treat hypothalamic obesity |
| Danilovich 2014 | Duration of follow‐up < 6 months |
| De Bock 2012 | Duration of drug treatment only 6 weeks |
| Delitala 1977 | Adults |
| Di Natale 1973 | Not an RCT |
| Diaz 2013 | Study aim, not all obese at baseline |
| Doggrell 2006 | Not an RCT |
| EUCTR2009‐016921‐32‐ES | A dietary therapy, intervention not relevant for this review |
| EUCTR2012‐000038‐20‐DE | Duration of treatment only 6 weeks |
| Fanghänel 2001 | Adults |
| Faria 2002 | Adults |
| Ferguson 1986 | Adults |
| Ferrara 2013 | Duration of follow‐up < 6 months |
| Fox 2015 | Not an RCT |
| Freemark 2007 | Not an RCT |
| Galloway 1975 | Adults |
| Gamski 1968 | Adults |
| Garnett 2010 | Not a pharmacological intervention |
| Genova 1967 | Study aim not to treat to obesity |
| Gill 1977 | Adults |
| Giovannini 1990 | Duration of treatment only 90 days |
| Godefroy 1968 | Adults |
| Goldrick 1973 | Adults |
| Goldstein 1993 | Adults |
| González Barranco 1974 | Adults |
| Griboff 1975 | Adults |
| Grube 2014 | Adults |
| Guazzelli 1987 | Adults |
| Gwinup 1967 | Duration of follow‐up in the placebo group only 13 weeks |
| Halpern 2006 | Adults |
| Hamilton 2003 | Duration of follow‐up only 3 months |
| Hansen 2001 | Adults |
| Haug 1973 | Adults |
| Hawkins 2012 | Not an RCT |
| Honzak 1976 | Adults |
| Hooper 1972 | Adults |
| Huston 1966 | Adults |
| IRCT2013021012421N1 | Aim of trial to treat fatty liver disease |
| IRCT2014020116435N1 | Not an RCT |
| Israsena 1980 | Duration of follow‐up only 4 months |
| James 2000 | Adults |
| Kasa‐Vubu 2008 | Not an RCT |
| Kay 2001 | Duration of treatment only 10 weeks |
| Kelly 2012 | 1 arm of the cross‐over trial was only followed up for 3 months after receiving the drug |
| Kelly 2013a | Not an RCT |
| Kelly 2013b | Not an RCT |
| Kendall 2014 | Not an RCT |
| Klein 2006 | Duration of follow‐up < 6 months |
| Kneebone 1968 | Adults |
| Knoll 1975 | Not an RCT |
| Komarnicka 1975 | Adults |
| Komorowski 1982 | Duration of treatment only 8 weeks |
| Kreze 1967 | Adults |
| Lamberto 1993 | Not an RCT |
| Leite 1971 | Adults |
| Lewis 1978 | Adults |
| Libman 2015 | Participants had type 1 diabetes ‐ secondary cause of obesity |
| Liebermeister 1969 | Adults |
| Liu 2013 | Adults |
| Lorber 1966 | Duration of treatment only 4 weeks |
| Love‐Osborne 2008 | The aim of the study was to treat insulin resistance, not all participants were obese |
| Maclay 1977 | Adults |
| Malchow‐Møller 1980 | Duration of follow‐up only 12 weeks |
| Marques 2016 | Not an RCT |
| McDuffie 2002 | Not an RCT |
| Molnár 2000 | Duration of follow‐up only 20 weeks |
| Muls 2001 | Adults |
| Nadeau 2015 | Participants had type 1 diabetes ‐ secondary cause of obesity |
| Nathan 2016 | A description paper of 2 trials which do not meet the inclusion criteria of this review |
| NCT00076362 | Aim of trial to treat hypothalamic obesity |
| NCT00284557 | Not a pharmacological intervention |
| NCT00775164 | Withdrawn prior to enrolment ‐ inadequate enrolment |
| NCT00845559 | Withdrawn prior to enrolment ‐ no reason provided |
| NCT01023139 | Not a pharmacological RCT ‐ all participants were given drugs then randomised to lifestyle intervention or control |
| NCT01061775 | Aim to treat hypothalamic obesity |
| NCT01107808 | Withdrawn prior to enrolment ‐ poor recruitment to the study |
| NCT01169103 | Intervention was a growth hormone therapy |
| NCT01242241 | Aim of the study: not treatment of obesity |
| NCT01329367 | Not a pharmacological intervention |
| NCT01332448 | Not an RCT |
| NCT01410604 | Duration of follow‐up only 3 months |
| NCT01456221 | Not a pharmacological intervention |
| NCT01910246 | Not an RCT |
| NCT02022956 | Not an RCT |
| NCT02063802 | Duration of follow‐up only 4 months |
| NCT02186652 | Not an RCT |
| NCT02378259 | Surgery intervention |
| NCT02398669 | No control group |
| NCT02438020 | Duration of follow‐up < 6 months |
| NCT02515773 | Participants had bipolar disorder and were critically ill. They were all treated with anti‐psychotics which can cause obesity (potential secondary cause of obesity) |
| Nwosu 2015 | Participants had type 1 diabetes ‐ secondary cause of obesity |
| O'connor 1995 | Adults |
| Park 2010 | Not an RCT |
| Pedrinola 1994 | Not an RCT |
| Persson 1973 | Adults |
| Plauchu 1967a | Adults |
| Plauchu 1967b | Adults |
| Plauchu 1972 | Adults |
| Pugnoli 1978 | Adults |
| Rauh 1968 | Duration of follow‐up only 12 weeks |
| Resnick 1967 | Adults |
| Rodos 1969 | Adults |
| Rodriguez 2007 | Not an RCT |
| Roed 1980 | Adults |
| Roginsky 1966 | Adults |
| Sabuncu 2004 | Adults |
| Sainani 1973 | Mainly adults |
| Scavo 1976 | Not an RCT |
| Shutter 1966 | Duration of treatment only 6 weeks |
| Spence 1966 | Not an RCT |
| Spranger 1963 | Duration of treatment only 4 weeks |
| Spranger 1965 | Duration of treatment only 4 weeks |
| Sproule 1969 | Adults |
| Stewart 1970 | Duration of follow‐up only 16 weeks |
| Sukkari 2010 | Not an RCT |
| TODAY study group 2013 | The aim of the study was to treat diabetes, not obesity |
| Tong 2005 | Adults |
| Toubro 2001 | Adults |
| Tsai 2006 | Not an RCT |
| Van Seters 1982 | Adults |
| Warren‐Ulanch 2008 | Not an RCT |
| Weintraub 1984 | Adults |
| Yanovski 2003 | Not an RCT |
| Yu 2013 | Duration of drug treatment only 10 weeks |
RCT: randomised controlled trial.