NCT00889876.

Trial name or title	Effect of exercise or metformin on nocturnal blood pressure and other risk factors for CVD among obese adolescents
Methods	Type of trial: interventional; randomised controlled trial Allocation: randomised Intervention model: factorial assignment Masking: open label Primary purpose: treatment
Participants	Condition: CVDs Enrolment: 100 Inclusion criteria: aged 13 to 19 years at inclusion date obesity according to sex‐ and age‐specific BMI (Cole 2000) reduced nocturnal systolic blood pressure fall (< 10%) signed informed consent by participant and parents Exclusion criteria: CVD insulin‐dependent diabetes mellitus participant on medications that are contraindicated during metformin treatment pregnancy mental or physical conditions limiting the ability to participate
Interventions	Intervention: metformin Comparator: exercise
Outcomes	Primary outcome: normalisation of nocturnal blood pressure dipping Secondary outcome: normalisation of insulin metabolism and cardiovascular structure and function
Starting date	Trial start date: February 2009 Trial completion date: December 2012 (estimated)
Contact information	Responsible party/principal investigator: Professor Claude Marcus, Karolinska Institutet, Karolinska Institute
Study identifier	NCT number: NCT00889876 Other trial ID numbers: 2008‐000461‐28
Official title	Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for Cardiovascular Disease (CVD) Among Obese Adolescents
Stated purpose of study	Quote: "The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors"
Notes	This trial has not been verified on the clinicaltrials.gov website since February 2011. We have attempted to contact the principal investigator via email; however, have not received a response. Trial sponsor: Karolinska Institutet