Cochrane Central Register of Controlled Trials (Cochrane Register of Studies)

Part I: Obesity 1. MESH DESCRIPTOR Obesity 2. MESH DESCRIPTOR Obesity, Morbid 3. MESH DESCRIPTOR Obesity, Abdominal 4. MESH DESCRIPTOR Pediatric Obesity 5. MESH DESCRIPTOR Overweight 6. MESH DESCRIPTOR Weight Loss 7. (adipos* or obes*):TI,AB,KY 8. (overweight* or over weight*):TI,AB,KY 9. (weight adj2 (reduc* or los* or control* or gain*)):TI,AB,KY 10. #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 Part II: Anti‐obesity drugs 11. MESH DESCRIPTOR Anti‐Obesity Agents 12. MESH DESCRIPTOR Appetite Depressants 13. ((anti obes* or antiobes* or weight loss) adj3 (agent* or drug* or medicine* or pharmac*)):TI,AB,KY 14. (appetite adj3 (suppress* or depress*)):TI,AB,KY 15. ((anorexi* or anorectic*) adj3 (agent* or drug*)):TI,AB,KY 16. anorectics:TI,AB,KY 17. metformin*:TI,AB,KY 18. exenatide*:TI,AB,KY 19. liraglutid*:TI,AB,KY 20. dulaglutid*:TI,AB,KY 21. albiglutid*:TI,AB,KY 22. taspoglutid*:TI,AB,KY 23. lixisenatid*:TI,AB,KY 24. semaglutid*:TI,AB,KY 25. orlistat*:TI,AB,KY 26. cetilistat*:TI,AB,KY 27. sibutramin*:TI,AB,KY 28. fluoxetin*:TI,AB,KY 29. rimonabant*:TI,AB,KY 30. lorcaserin*:TI,AB,KY 31. benzphetamin*:TI,AB,KY 32. diethylpropion*:TI,AB,KY 33. phendimetrazin*:TI,AB,KY 34. mazindol*:TI,AB,KY 35. (phentermin* or chlorphentermin* or mephentermin*):TI,AB,KY 36. (phentermin* adj3 topiramat*):TI,AB,KY 37. (bupropion* adj3 naltrexon*):TI,AB,KY 38. (bupropion* adj3 zonisamid*):TI,AB,KY 39. beloranib*:TI,AB,KY 40. velneperit*:TI,AB,KY 41. tesofensin*:TI,AB,KY 42. #11 or #12 or #13 or #14 or #15 or#16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30 or #31 or #32 or #33 or #34 or #35 or #36 or #37 or #38 or #39 or #40 or #41 Part III: Part I + Part II 43. #10 and #42 44. MESH DESCRIPTOR Obesity WITH QUALIFIERS DT 45. MESH DESCRIPTOR Obesity, Morbid WITH QUALIFIERS DT 46. MESH DESCRIPTOR Weight Loss WITH QUALIFIERS DT 47. MESH DESCRIPTOR Overweight WITH QUALIFIERS DT 48. #43 or #44 or #45 or #46 or #47 Part IV: Population 49. MESH DESCRIPTOR Adolescent 50. MESH DESCRIPTOR Child 51. MESH DESCRIPTOR Pediatrics 52. minors:TI,AB,KY 53. (boy or boys or boyhood):TI,AB,KY 54. girl*:TI,AB,KY 55. (kid or kids):TI,AB,KY 56. (child* or schoolchild*):TI,AB,KY 57. adolescen*:TI,AB,KY 58. juvenil*:TI,AB,KY 59. youth*:TI,AB,KY 60. (teen* or preteen*):TI,AB,KY 61. (underage* or under age*):TI,AB,KY 62. pubescen*:TI,AB,KY 63. p?ediatric*:TI,AB,KY 64. #49 or #50 or #51 or #52 or #53 or #54 or #55 or #56 or #57 or #58 or #59 or #60 or #61 or #62 or #63 Part V: Part III AND IV 65. #48 and #64 66. MESH DESCRIPTOR Pediatric Obesity WITH QUALIFIERS DT 67. #65 or #66

MEDLINE (OvidSP)

Part I: Obesity 1 Obesity/ 2 Obesity, Morbid/ 3 Obesity, Abdominal/ 4 Pediatric Obesity/ 5 Overweight/ 6 Weight Loss/ 7 (adipos* or obes*).tw. 8 (overweight* or over weight*).tw. 9 (weight adj2 (reduc* or los* or control* or gain*)).tw. 10 or/1‐9 Part II: Anti‐obesity drugs 11 Anti‐Obesity Agents/ 12 Appetite Depressants/ 13 ((anti obes* or antiobes* or weight loss) adj3 (agent* or drug* or medicine* or pharmac*)).tw. 14 (appetite adj3 (suppress* or depress*)).mp. 15 ((anorexi* or anorectic*) adj (agent* or drug*)).tw. 16 anorectics.tw. 17 metformin*.mp. 18 exenatide*.mp. 19 liraglutid*.mp. 20 dulaglutid*.mp. 21 albiglutid*.mp. 22 taspoglutid*.mp. 23 lixisenatid*.mp. 24 semaglutid*.mp. 25 orlistat*.mp. 26 cetilistat*.mp. 27 sibutramin*.mp. 28 fluoxetin*.mp. 29 rimonabant*.mp. 30 lorcaserin*.mp. 31 benzphetamin*.mp. 32 diethylpropion*.mp. 33 phendimetrazin*.mp. 34 mazindol*.mp. 35 (phentermin* or chlorphentermin* or mephentermin*).mp. 36 ((phentermin* adj3 topiramat*) or phentermine?topiramat*).mp. 37 ((bupropion* adj3 naltrexon*) or bupropion?naltrexon*).mp. 38 ((bupropion* adj3 zonisamid*) or bupropion?zonisamid*).mp. 39 beloranib*.mp. 40 velneperit*.mp. 41 tesofensin*.mp. 42 or/11‐41 Part III: Part I + Part II and additional MeSH/subheading combination 43 10 and 42 44 Obesity/dt [drug therapy] 45 Obesity, Morbid/dt [drug therapy] 46 Weight Loss/dt [drug therapy] 47 Overweight/dt [drug therapy] 48 or/43‐47 Part IV: Population [based onLeclercq 2013] 49 Adolescent/ 50 Child/ 51 Pediatrics/ 52 minors.tw. 53 (boy or boys or boyhood).tw. 54 girl*.tw. 55 (kid or kids).tw. 56 (child* or schoolchild*).tw. 57 adolescen*.tw. 58 juvenil*.tw. 59 youth*.tw. 60 (teen* or preteen*).tw. 61 (underage* or under age*).tw. 62 pubescen*.tw. 63 p?ediatric*.tw. 64 or/49‐63 Part V: Part III AND IV and additional MeSH/subheading combination 65 48 and 64 66 Pediatric Obesity/dt 67 65 or 66 Part VI: Study filter [Cochrane Handbook 2008 RCT filter ‐ sensitivity max. version] 68 randomized controlled trial.pt. 69 controlled clinical trial.pt. 70 randomi?ed.ab. 71 placebo.ab. 72 drug therapy.fs. 73 randomly.ab. 74 trial.ab. 75 groups.ab. 76 or/68‐75 77 exp animals/ not humans/ 78 76 not 77 Part VII: Part V + Part VI 79 67 and 78

Embase (OvidSP)

Part I: Obesity 1 obesity/ 2 morbid obesity/ 3 abdominal obesity/ 4 childhood obesity/ 5 weight reduction/ 6 (adipos* or obes*).tw. 7 (overweight* or over weight*).tw. 8 (weight adj2 (reduc* or los* or control* or gain*)).tw. 9 or/1‐8 Part II: Anti‐obesity drugs 10 antiobesity agent/ 11 anorexigenic agent/ 12 ((anti obes* or antiobes* or weight loss) adj3 (agent* or drug* or medicine* or pharmac*)).tw. 13 (appetite adj3 (suppress* or depress*)).tw. 14 ((anorexi* or anorectic*) adj (agent* or drug*)).tw. 15 anorectics.tw. 16 metformin*.mp. 17 exenatide*.mp. 18 liraglutid*.mp. 19 dulaglutid*.mp. 20 albiglutid*.mp. 21 taspoglutid*.mp. 22 lixisenatid*.mp. 23 semaglutid*.mp. 24 orlistat*.mp. 25 cetilistat*.mp. 26 sibutramin*.mp. 27 fluoxetin*.mp. 28 rimonabant*.mp. 29 lorcaserin*.mp. 30 benzphetamin*.mp. 31 diethylpropion*.mp. 32 phendimetrazin*.mp. 33 mazindol*.mp. 34 (phentermin* or chlorphentermin* or mephentermin*).mp. 35 ((phentermin* adj3 topiramat*) or phentermine?topiramat*).mp. 36 ((bupropion* adj3 naltrexon*) or bupropion?naltrexon*).mp. 37 ((bupropion* adj3 zonisamid*) or bupropion?zonisamid*).mp. 38 beloranib*.mp. 39 velneperit*.mp. 40 tesofensin*.mp. 41 or/10‐40 Part III: Part I + Part II and additional MeSH/subheading combination 42 9 and 41 43 obesity/dt [drug therapy] 44 morbid obesity/dt [drug therapy] 45 weight reduction/dt [drug therapy] 46 or/42‐45 Part IV: Population [adapted fromLeclercq 2013] 47 juvenile/ 48 adolescent/ 49 child/ 50 preschool child/ 51 schoolchild/ 52 pediatrics/ 53 minors.tw. 54 (boy or boys or boyhood).tw. 55 girl*.tw. 56 (kid or kids).tw. 57 (child* or schoolchild*).tw. 58 adolescen*.tw. 59 juvenil*.tw. 60 youth*.tw. 61 (teen* or preteen*).tw. 62 (underage* or under age*).tw. 63 pubescen*.tw. 64 p?ediatric*.tw. 65 or/47‐64 Part V: Part III AND IV and additional MeSH/subheading combination 66 46 and 65 67 childhood obesity/dt 68 66 or 67 Part VI: Study filter [Wong 2006afilter – BS version] 69 random*.tw. or clinical trial*.mp. or exp health care quality/ Part VII: Part V + Part VI 70 68 and 69 71 limit 70 to embase

LILACS (IAHx)

((MH:"Obesity" OR MH:"Obesity, Morbid" OR MH:"Obesity, Abdominal" OR MH:"Pediatric Obesity" OR MH:"Overweight" OR MH:"Weight Loss" OR adipos$ OR obes$ OR overweight$ OR "over weight" OR sobrepes$ OR "exceso de peso" OR "excesso de peso" OR "weight reduction" OR "weight loss" OR "weight control") AND (MH:"Obesity/drug therapy" OR MH:"Obesity, Morbid/drug therapy" OR MH:"Overweight/drug therapy" OR MH:"Weight Loss/drug therapy" OR MH:"Anti‐Obesity Agents" OR MH:"Appetite Depressants" OR "farmacos antiobesidad" OR "farmacos antiobesidade" OR "depresores del apetito" OR "depressores do apetite" OR metformin$ OR exenatide$ OR liraglutid$ OR dulaglutid$ OR albiglutid$ OR taspoglutid$ OR lixisenatid$ OR semaglutid$ OR orlistat$ OR cetilistat$ OR sibutramin$ OR fluoxetin$ OR rimonabant$ OR lorcaserin$ OR benzphetamin$ OR diethylpropion$ OR phendimetrazin$ OR mazindol$ OR phentermin$ or chlorphentermin$ or mephentermin$ OR (phentermin$ AND topiramat$) OR (bupropion$ AND (naltrexon$ OR zonisamid$)) OR beloranib$ OR velneperit$ OR tesofensin$) AND (MH:"Adolescent" OR MH:"Child" OR MH:"Pediatrics" OR minors OR boy OR boys OR girl$ OR kid OR kids OR child$ OR schoolchild$ OR escolar$ OR adolescen$ OR preadolescen$ OR juvenil$ OR juventud$ OR youth$ OR teen$ OR preteen$ OR underage$ OR pubescen$ OR paediatri$ OR pediatri$ OR joven$ OR jovem$ OR niños OR niñas OR crianca$ OR menin$ OR "menor de edad" OR "menores de edad" OR "menor de idade" OR "menores de idade") OR MH:"Pediatric Obesity/drug therapy") + Controlled Clinical Trial

PubMed (only subsets not available on Ovid)

#1 Part I: Obesity adipos*[tw] OR obes*[tw] OR overweight*[tw] OR over weight*[tw] OR weight reduc*[tw] OR weight los*[tw] OR weight control*[tw] OR weight gain*[tw] #2 Part II: Antiobesity drugs anti obesity agent*[tw] OR antiobesity agent*[tw] OR anti obesity drug*[tw] OR antiobesity drug*[tw] OR weight loss agent[tw] OR weight loss drug[tw] OR appetite suppress*[tw] OR appetite depress*[tw] OR anorexigenic agent*[tw] OR anorexigenic drug*[tw] OR anorectics[tw] OR metformin*[tw] OR exenatide*[tw] OR liraglutid*[tw] OR dulaglutid*[tw] OR albiglutid*[tw] OR taspoglutid*[tw] OR lixisenatid*[tw] OR semaglutid*[tw] OR orlistat*[tw] OR cetilistat*[tw] OR sibutramin*[tw] OR fluoxetin*[tw] OR rimonabant*[tw] OR lorcaserin*[tw] OR benzphetamin*[tw] OR diethylpropion*[tw] OR phendimetrazin*[tw] OR mazindol*[tw] OR phentermin*[tw] OR chlorphentermin*[tw] OR mephentermin*[tw] OR topiramat*[tw] OR bupropion*[tw] OR naltrexon*[tw] OR zonisamid*[tw] OR beloranib*[tw] OR velneperit*[tw] OR tesofensin*[tw] #3 Part III: Part I + Part II #1 AND #2 #4 Part IV: Population minors[tw] OR boy[tw] OR boys[tw] OR boyhood[tw] OR girl*[tw] OR kid[tw] OR kids[tw] OR child*[tw] OR schoolchild*[tw] OR adolescen*[tw] OR juvenil*[tw] OR youth*[tw] OR teen*[tw] OR preteen*[tw] OR underage*[tw] OR under age*[tw] OR pubescen*[tw] OR paediatric*[tw] OR pediatric*[tw] #5 Part V: Part III AND IV #3 AND #4 #6 Part VI: Limiting to subsets not available on Ovid #5 not medline[sb] not pmcbook

ICTRP Search Portal (Standard search)

obes* AND child* OR obes* AND schoolchild* OR obes* AND adolesc* OR obes* AND young* OR obes* AND pediatric* OR obes* AND teen* OR obes* AND preteen* OR obes* AND juvenil* OR obes* AND minors OR obes* AND boy* OR obes* AND girl* OR obes* AND kids OR obes* AND youth* OR obes* AND underage* OR obes* AND pube* OR overweight* AND child* OR overweight* AND schoolchild* OR overweight* AND adolesc* OR overweight* AND young* OR overweight* AND pediatric* OR overweight* AND teen* OR overweight* AND preteen* OR overweight* AND juvenil* OR overweight* AND minors OR overweight* AND boy* OR overweight* AND girl* OR overweight* AND kids OR overweight* AND youth* OR overweight* AND underage* OR overweight* AND pube*

ClinicalTrials.gov (Expert search)

( obese OR overweight OR obesity ) [DISEASE] AND ( drug or drugs OR agent OR agents OR appetite OR metformin OR exenatide OR liraglutide OR dulaglutide OR albiglutide OR taspoglutide OR lixisenatide OR semaglutide OR orlistat OR cetilistat OR sibutramine OR fluoxetine OR rimonabant OR lorcaserin OR benzphetamine OR diethylpropion OR phendimetrazine OR mazindol OR phentermine OR chlorphentermine OR mephentermine OR topiramate OR bupropion OR naltrexone OR zonisamide OR beloranib OR velneperit OR tesofensine ) [TREATMENT] AND INFLECT EXACT "Child" [AGE‐GROUP]