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. Author manuscript; available in PMC: 2019 Apr 18.
Published in final edited form as: Annu Rev Immunol. 2018 Apr 26;36:411–433. doi: 10.1146/annurev-immunol-042617-053352

Figure 3.

Figure 3

The phosphorylation networks of IL-2 signaling in effector T lymphocytes. Global phosphoproteomic studies have revealed the range of tyrosine (yellow circles) and serine/threonine phosphorylations (peach circles) regulated following IL-2 stimulation of cytotoxic T lymphocytes. These phosphorylations are on diverse proteins involved in multiple aspects of T cell biology and include scaffold proteins, proteins that can direct gene expression, and cytoskeletal regulators. These comprehensive phosphoproteomic studies highlight that IL-2 signaling involves much more than JAK1/3-STAT5 and reinforce the importance of serine/threonine kinase pathways in IL-2 responses.