Table 2. Association between carbamazepine (CBZ) treatment and postoperative delirium (PODE).
| Variable | PODE (n = 221) |
No PODE (n = 691) |
P value |
|---|---|---|---|
| Preoperative CBZ therapy (n, %) | 182 (82.4%) | 506 (73.2%) | 0.006 |
| Preoperative CBZ dose (mg) | 708.14 ± 68.10 | 599.49 ± 67.38 | <0.001 |
| Duration of CBZ use (years) | 5.96 ± 0.77 | 4.94 ± 0.63 | <0.001 |
| Preoperative CBZ (μg/mL)* | 6.11 ± 1.21 | 5.26 ± 1.05 | <0.001 |
| Postoperative CBZ (μg/mL)& | 1.40 ± 0.18 | 1.42 ± 0.23 | 0.127 |
*Serum CBZ level measured 24 h before surgery
&Serum CBZ level measured 24 h after surgery
Values are expressed as mean ± standard deviation unless otherwise specified.