Table 1. Antibacterial effect of 10-UDYA tested against four oral Streptococcus spp.
|
Test parameters |
10-undecynoic acid (mg/ml) | Amoxicillin (μg/ml) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC | MBC | MBIC90 | MBBC | MBEC50 | MIC | MBC | MBIC90 | MBBC | MBEC50 | |
|
S. mutans UA159 |
2.5 | 5.0 | 2.5 | 5.0 | 7.0 | 1.95[44] | 2.0 | 7.8[44] | 10 | NE |
|
S. mutans NCTC 10449 |
2.5 | 5.0 | 2.5 | 5.0 | 7.0 | 2.0 | 2.0 | 10 | 10 | NE |
|
S. sobrinus SL1 |
2.5 | 5.0 | 2.5 | 5.0 | 7.0 | 2.0 | 2.0 | 10 | 10 | NE |
|
S. sobrinus NIDR 6715–15 |
2.5 | 5.0 | 2.5 | 5.0 | 7.0 | 2.0 | 2.0 | 10 | 10 | NE |
Abbreviations: MIC—minimal inhibitory concentration, MBC—minimal bactericidal concentration, MBIC90—minimal biofilm inhibitory concentration that reduce the growth of biofilm at least in 90%, MBBC—minimal biofilm biocidal concentration, MBEC50—minimal biofilm eradication concentration that detach biofilm in at least 50%, NE—no effect/ susceptibility at the maximal tested concentration (i.e., 500 μg/ml).