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. 2019 Apr 18;14(4):e0215394. doi: 10.1371/journal.pone.0215394

Fig 3. ChIP-seq identified novel K-RTA and K8 binding sequences on KSHV as well as on the cellular genome.

Fig 3

Analysis of the K-RTA binding sites identified K-RTA specific motif AGAGAGAGGA (motif RB) with strong enrichment among the DNA sequences on both host and viral genome and K8-specific motif AGAAAAATTC (motif RV) with a strong central enrichment among the DNA sequences on viral genome bound by K-RTA. Additionally analysis of the K8 enriched sites showed a motif AAAATGAAAA (motif KB) which also has a strong enrichment among the DNA sequences on both host and viral genome.