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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Cephalalgia. 2018 May 17;39(1):77–90. doi: 10.1177/0333102418777507

Figure 7.

Figure 7.

mTBI increases cephalic mechanical hypersensitivity to a low-dose of NTG 2 weeks after closed head injury. Post-sham or injury, C57BL/6J mice received either a vehicle or low dose NTG (0.1 mg/kg, ip) every day over 9 days, and tested every 4th day (days 1.5, 9). (a) Basal thresholds, assessed prior to vehicle or NTG administration, revealed that mTBI animals treated with low dose NTG had significantly lower basal cephalic thresholds than their sham counterparts. p < 0.001 treatment, time and interaction; two-way RM ANOVA, Holm-Sidak post hoc analysis, ***p < 0.001, n = 8/group. (b) In the same mice tested 2 h post NTG/vehicle, NTG evoked hyperalgesia that did not differ between sham and mTBI groups. mTBI increases the development of cephalic hypersensitivity to a low dose of NTG.