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. Author manuscript; available in PMC: 2019 Apr 18.
Published in final edited form as: Neuropharmacology. 2017 Aug 1;125:254–262. doi: 10.1016/j.neuropharm.2017.07.031

Fig. 3. Modafinil induces hyperactivity in mice at high doses.

Fig. 3.

Modafinil dose dependently increased horizontal activity (A) at 32 mg/kg compared to all other doses. No significant changes in specific exploration (hole poking) (B) were seen at any dose of modafinil. Diversive exploration (rearing) (C) was significantly increased compared to control at the highest dose. The 32 mg/kg dose also significantly decreased circumscribed, meandering locomotor patterns as measured by spatial d (D). Data presented as mean + SEM, * denotes p < 0.05 vs. vehicle (Veh), ** denotes p < 0.01 vs. Veh.