TABLE 3.
Univariate analysis of predictors of HCC recurrence
| Predictor | HR (95% Cl) | P |
|---|---|---|
| No. lesions | ||
| 2 (vs 1) | 1.4 (0.6–3.0) | 0.41 |
| 3 (vs 1) | 5.5(2.2–13.4) | <0.001 |
| Days from HOC to LT | 1.0 (1.0–1.0) | 0.49 |
| No. LRT | 1.2 (0.9–1.5) | 0.13 |
| Cold ischemia time (per 1 h increase from 8 h | 0.95 (0.87–1.05) | 0.31 |
| Donor age (≥ 60 y vs < 60 y) | 0.99 (0.41–2.39) | 0.98 |
| Microvascular invasion | 13.1 (6.8–25.2) | <0.001 |
| Explant grade (as continuous variable) | 1.8 (1.3–2.5) | <0.001 |
| Pathologic stage outside Milan | 8.9 (3.9–20.6) | <0.001 |
| Age at HCC diagnosis | 1.01 (1.0–1.1) | 0.47 |
| Sex (female) | 2.3 (1.2–4.3) | 0.01 |
| Diagnosis of chronic liver disease | ||
| HBV (vs HCV) | 1.1 (0.5–2.2) | 0.85 |
| Other (vs HCV) | 1.9 (0.9–4.1) | 0.11 |
| Race (vs white) | ||
| African | 1.4 (0.4–4.9) | 0.56 |
| Asian | 0.7 (0.3–1.4) | 0.26 |
| Hispanic | 0.7 (0.3–1.8) | 0.50 |
| Others | 0.00 | 0.99 |
| AFP slope (vs −7.5 to 0) | ||
| <−7.5 | 1.8 (0.7–4.4) | 0.21 |
| 0–7.5 | 1.9 (0.9–4.1) | 0.08 |
| >7.5 | 3.9(1.5–10.2) | 0.005 |