Table:
Studies Comparing 0.9% Saline to Balanced Fluid Resuscitation
| Study | Population | Design | Sample Size | Outcome | 0.9% Saline | Balanced | P-Value |
|---|---|---|---|---|---|---|---|
| Yunos et al 2012 [15] | Adult ICU | Pre/Post | 1,533 | Mortality | 15% | 13% | 0.44 |
| Raghunathan et al 2014 [10] | Adult sepsis | Matched cohort | 6,730 | Mortality | 23% | 20% | 0.001 |
| Yunos et al 2012 [15] | Adult ICU | Pre/Post | 1,533 | AKI | 14% | 8.4% | <0.001 |
| SPLIT Trial 2015 [14] | Adult ICU | Cross-over | 2,092 | AKI | 9.2% | 9.6% | 0.77 |
| Self et al 2018 [11] | Adults | RCT | 13,347 | MAKE30 | 5.6% | 4.7% | 0.01 |
| Semler et al 2018 [12] | Adult ICU | RCT | 15,802 | MAKE30 | 15.4% | 14.3% | 0.04 |
| Weiss et al 2017 [13] | Pediatric sepsis | Matched cohort | 4,234 | Mortality | 7.9% | 7.2% | 0.20 |
| Emrath et al 2017 [8] | Pediatric sepsis/ICU | Matched cohort | 10,318 | Mortality | 15% | 13% | 0.051 |
| Ngo et al 2001 [9] | Pediatric dengue fever | RCT | 222 | Shock recovery | 93% | 80% | 0.022 |
ICU, intensive care unit; RCT, randomized controlled trial; NA, not applicable; RR, relative risk; CI, confidence interval; AKI, acute kidney injury; MAKE30, major adverse kidney events by 30 days