IRCT2015101024459N1.

Trial name or title	Evaluation of the efficacy of Ahmed Glaucoma Valve Implantation with and without Mitomycin C during surgery in patients with glaucoma
Methods	Study design: parallel group, randomized controlled trial Planned enrolment: 60 participants Unit of analysis: participant (one study eye per participant) Sample size calculation: not reported
Participants	Country: Iran Inclusion criteria: 18 years of age or older; uncontrolled glaucoma; candidate for aqueous shunt surgery Exclusion criteria: active iris neovascularization, anterior staphyloma, breastfeeding, pregnancy, previous shunt surgery, corneal lesions that prevent IOP measurement
Interventions	MMC group: 1‐stage Ahmed valve implant with MMC (0.02%) No MMC group: Ahmed valve implant with placebo (balanced salt solution)
Outcomes	Primary outcome: IOP Secondary outcomes: tube‐corneal contact, number of antiglaucoma medications, hyphema, retraction of tube from anterior chamber, tube/implant exposure, flat chamber/transient hypotony, choroidal effusion, blocked tube Length of follow‐up: postoperative day 1, week 1, and months 1, 3, 6, and 12
Starting date	November 2015
Contact information	Dr. Ghasem Fakhraee Farabi Eye Hospital Tehran University of Medical Sciences
Notes	Conflicts of interest: not reported