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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Nature. 2019 Mar 20;568(7752):420–423. doi: 10.1038/s41586-019-1026-5

Figure 1: Filamentous tau pathology of CTE.

Figure 1:

a, Perivascular staining of tau inclusions in the depth of a sulcus (S) in the frontal cortex of CTE case 1 using antibody AT8 (pS202/pT205 tau; brown). Nuclei were counterstained blue. Scale bar, 100 μm. b, Perivascular staining of tau inclusions in the subependymal regions of CTE cases 1, 2 and 3 using antibody AT8 (brown). Nuclei were counterstained blue. Scale bar, 100 μm. c, Staining of tau inclusions using antibody AT100 (pT212/pS214/pT217 tau; brown) and Gallyas-Braak silver staining (black) of inclusions in the temporal cortex of CTE case 1. Nuclei were counterstained blue. Scale bar, 50 μm. d, Negative-stain electron micrographs of a type I and a type II tau filament extracted from temporal cortex of CTE case 1. Scale bar, 50 nm.