Figure 4.

Effects of adult fluoxetine (FLX) exposure on body weight gain and the tail suspension test. (a) Body weight increased across days of treatment (postnatal day (PD) 70–84), regardless of FLX or water-control (CON) conditions. However, when compared to CON mice, FLX-exposed mice displayed lower weight gain as of the second day of antidepressant exposure (PD71), remaining lower until PD78 (p<0.05). Twenty-one days post FLX exposure (PD105) no differences in body weight were noted between the groups (p>0.05; inset). Data are presented as average weight across days and antidepressant exposure (mean ± standard error of the mean (SEM), in g). (b) Twenty-four hours post antidepressant exposure (PD85), a separate group of adult mice was tested in the tail suspension test. FLX-exposed mice displayed higher time (s) to adopt a posture of immobility, (c) as well as a lower time spent immobile, when compared to CON mice (p<0.05). Data are presented as total time in seconds (mean ± SEM). *Significantly different when compared to CON (p<0.05).