Figure 5.

Enduring effects of adult fluoxetine (FLX) exposure on reward-related behavior. (a) Three-weeks after adult antidepressant exposure, FLX-pretreated mice displayed decreased sensitivity to 5 and 7.5 mg/kg cocaine, when compared to water-pretreated control (CON) mice exposed to the same doses of cocaine (n=10 per experimental group; p<0.05). *Within cocaine group comparison (p<0.05). αSignificantly different when compared to age-matched controls conditioned to saline (p<0.05). (b) Adult FLX pretreatment reduced preference for a 1% sucrose solution three weeks after antidepressant exposure (n=12 per group; p<0.05). (c) No differences in total liquid intake were observed between the experimental groups (p>0.05).