Fig. 1.
Therapeutic effectiveness of drug-loaded exosome for pancreas cancer. Human foreskin fibroblast (BJ)-derived exosome was loaded with shRNA for KrasG12D using electroporation. Ten days after orthotopic administration of human pancreas cancer cells, approximately 108 iExosomes (0.15–0.20 μg/injection) were intraperitoneally injected into the nude mice every other days until 200 days. Time course semi-quantitative data for growth of luciferase-expressing pancreas tumor in mice revealed that iExosomes but not iLiposomes completely suppress tumor volume in pancreas tumor-bearing mice until 200 days. Reprinted with permission from [15]