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. 2019 Apr 12;9:262. doi: 10.3389/fonc.2019.00262

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Copyright © 2019 Zhao, Yu, Sui, Gong, Zhou, Chen, Gong and Hao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association of DEPDC1with advanced stage, metastasis and malignant degree of breast cancer was analyzed from TCGA_BRCA dataset. (A) Correlation analysis was performed between expression level of DEPDC1 and clinical AJCC stages. DEPDC1 was correspondingly increased with the increase of clinical AJCC stage of breast cancer. (B) Constituent ratio with high level of DEPDC1 was drastically different between normal samples and I, II, III, or IV stage of breast cancer tissues. (C) DEPDC1expression level was increased as breast cancer tumor size (T) growth and distant metastatic relapse status (D) from TCGA_BRCA data. (E) Scatter plot of relative DEPDC1 mRNA level in breast cancer patients with and without recurrence was compared. (F) The expression of DEPDC1 was higher in TNBC than in non-TNBC of breast cancer. *p < 0.05, **p < 0.01 and ****p < 0.0001.