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. 2019 Apr 12;9:262. doi: 10.3389/fonc.2019.00262

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Copyright © 2019 Zhao, Yu, Sui, Gong, Zhou, Chen, Gong and Hao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEPDC1 improved the migration and invasion of breast cancer cells in vitro assay. (A) overexpression of DEPDC1 promoted MCF-7 cells migration distance. (B) Decreased migration rate was determined in DEPDC1-deletion MDA-MB-231 cells. (C,D) The representative images of the migration assays for MCF-7 and MDA-MB-231 cells at 0 and 24 h were presented. (E,F) Cells were subjected to invasion assay after altering DEPDC1 expression 48 h using transwell assay. (G) GSEA showed that DEPDC1 high expression was positively correlated with invasive breast cancer. (H) The gene signatures of breast cancer metastasis were highly enriched in patients with DEPDC1 high expression. *p < 0.05, **p < 0.01.