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. 2019 Apr 12;9:262. doi: 10.3389/fonc.2019.00262

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Copyright © 2019 Zhao, Yu, Sui, Gong, Zhou, Chen, Gong and Hao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEPDC1 activated PI3K/AKT/mTOR signaling pathway. (A) GSEA showed that DEPDC1 level was positively associated with PI3K_AKT_ACTIVATION gene set in breast cancer. Samples from TCGA_BRCA were divided into low- and high- DEPDC1 expression groups. (B) Gene signatures of PI3K/AKT/mTOR signaling activation were enriched in patients with DEPDC1-higher expression group. (C) The phosphorylation of PI3K p85 (Tyr458), AKT (Ser473) and mTOR (Ser2448) were activated when DEPDC1 were overexpressed in MCF-7. NES, normalized enrichment score; FDR, false discovery rate; FDR < 0.25 is a widely accepted cutoff for the identification of biologically significant gene sets.