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. 2019 Apr 12;10:380. doi: 10.3389/fphys.2019.00380

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Copyright © 2019 Afshar, Safaei, Nickerson, Hunter and Suresh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intracellular glucose concentration vs. extracellular glucose concentration in Caco2 in the presence/absence of Apical GLUT2 with different number of SGLT1 transporter (A) Output of model with apical GLUT2 (B) Model does not have apical GLUT2 (C) model does not have apical GLUT2 and the number of SGLT1 is doubled (D) model does not have apical GLUT2 and the number of SGLT1 is 3-fold higher. Experimental data points and error bars were digitally extracted from Zheng et al. (2012). Strips for the model predictions represent the range of values generated by setting V_b = mV_c, m = 0.1, 1, 10, 100, ∞.