Table 1.
Inhibition of ZIKV replication with ATA.
| ZIKV strain | Drug | Treatment | Hours | Cells | CC50 (μM)1 | IC50 (μM)2 | SI3 |
|---|---|---|---|---|---|---|---|
| Paraiba/2015 | ATA | Post | 36 | Vero | >1,000 | 13.87 ± 1.09 | >72.10 |
| Paraiba/2015 | ATA | Post | 36 | A549 | >1,000 | 33.33 ± 1.13 | >26.26 |
| Paraiba/2015 | ARB | Post | 36 | Vero | 74.71 ± 1.09 | 18.19 ± 1.16 | 4.11 |
| Paraiba/2015 | ARB | Post | 36 | A549 | 114.6 ± 1.08 | 51.87 ± 1.08 | 2.21 |
| Uganda/1947 | ATA | Post | 48 | Vero | >1,000 | 15.07 ± 1.19 | >66.35 |
| Nigeria/1968 | ATA | Post | 60 | Vero | >1,000 | 15.97 ± 1.02 | >62.62 |
| Puerto Rico/2015 | ATA | Post | 48 | Vero | >1,000 | 17.55 ± 1.16 | >56.98 |
| French Polynesia/2013 | ATA | Post | 48 | Vero | >1,000 | 13.92 ± 1.01 | >76.80 |
| Brazil/2015 | ATA | Pre | 12 | Vero | >1,000 | 14.33 ± 1.06 | >69.78 |
| Brazil/2015 | ATA | Pre | 24 | Vero | >1,000 | 13.18 ± 1.05 | >75.87 |
| Brazil/2015 | ATA | Pre | 48 | Vero | >1,000 | 12.59 ± 1.02 | >79.42 |
| Brazil/2015 | ATA | Pre | 72 | Vero | >1,000 | 10.50 ± 1.05 | >95.24 |
1Median cytotoxicity concentration 50 (CC50). 2Median inhibitory concentration 50 (IC50). 3SI (Selective index) = CC50/IC50. For ATA, the SI was calculated considering a CC50 of 1,000 μM.