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. 2018 Nov 28;219(10):1586–1595. doi: 10.1093/infdis/jiy685

Figure 2.

Figure 2.

Diminished plasmablast responses after repeated trivalent inactivated influenza vaccine (TIV) receipt. Plasmablast responses were measured at days 6–8 after vaccination in repeated TIV recipients. A, TIV-specific binding titer of immunoglobulin G (IgG) plasmablast-derived polyclonal Abs (PPAbs; left panel) and IgG PPAbs (right panel) after TIV receipt in each year. The titer of each PPAb sample, determined by serial dilution, is presented as a vertical bracket that indicates the upper and lower boundaries of the estimated titer value. The black dots indicate estimated geometric mean titer from the fit of a regression model for all individuals in each year. B, Frequency of TIV-specific immunoglobulin A (IgA) Ab-secreting cells (ASCs; left panel) and IgG ASCs (right panel) after vaccination in each year. The horizontal bars indicate means of frequency values. C, Percentage of TIV-specific IgA ASCs (left panel) and IgG ASCs (right panel) out of the total number of IgA or IgG ASCs after vaccination in each year. The horizontal bars indicate means of percentage values. P values for pairs of compared means are adjusted for multiple comparisons and marked within each graph. See Supplementary Figures 2A–C and 6–9 for details of statistical analysis.