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. 2019 Apr 12;10:754. doi: 10.3389/fimmu.2019.00754

Figure 3.

Figure 3

Loss of autophagy in myeloid cells leads to neutrophilia and mortality during CP infection. (A) Atg16l1fl/fl and Atg16l1fl/fl Lysmcre mice were infected with 2.5 × 106 IFU CP i.t. and mortality was assessed (n = 5–6). (B–L) Atg16l1fl/fl and Atg16l1fl/fl Lysmcre mice were infected with 1.0 × 106 IFU CP i.t. and mice were sacrificed 3, 5, and 9 days after infection (n = 9–13, pooled from two experiments). (B) Bacterial burden in the lungs. (C) Total cells in the BALF. (D) BALF Alveolar macrophages. (E) BALF T-cells. (F) BALF neutrophils. (G) BALF DCs. (H) BALF IFN-γ. (I) BALF IL-6. (J) BALF IL-12p40. (K) BALF CXCL1. (L) BALF CXCL2. Data are mean ± SEM. Significance was assessed by students t-test. Survival curve was compared using the Log-Rank (Mantel-Cox) Test. *p < 0.05, **p < 0.01, ***p < 0.001.