Summary of findings 2. Summary of findings.

Chemotherapy followed by radiotherapy compared withradiotherapy for early stage cervical cancer
Patient or population: patients with early stage cervical cancer Settings: inpatient or outpatient Intervention: chemotherapy followed by radiotherapy Comparison: radiotherapy
Outcomes	Illustrative comparative risks* (95% CI)		Relative effect (95% CI)	No of Participants (studies)	Quality of the evidence (GRADE)
	Assumed risk	Corresponding risk
	Radiotherapy	Chemotherapy followed by radiotherapy
Disease progression Follow‐up: median 30 months	297 per 1000	376 per 1000 (81 to 933)	HR 1.34 (0.24 to 7.66)	71 (1 study)	⊕⊕⊝⊝ low1
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; HR: Hazard ratio;
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

¹ Imprecision in point estimate for Tattersall 1992, indicated by large CI due to low number of women with disease progression. This uncertainty means we are unsure whether to use radiotherapy alone or sequentially in combination with chemotherapy.