7. Radiotherapy and chemotherapy versus radiotherapy: hazard ratios in included trials.

Outcome	Study	Comparison	ln(HR)	SE[ln(HR)]	HR (95% CI)	Notes
Death
	Peters 2000	radiotherapy vs. radiotherapy+chemotherapy	0.67	NR	1.96	Cox HR, reported in paper
		radiotherapy+chemotherapy vs. radiotherapy	‐0.57	0.27	0.57 (0.33 to 0.96)*	Estimated from Kaplan‐Meier plots
		radiotherapy+chemotherapy vs. radiotherapy	‐0.71	0.26	0.49 (0.43 to 0.56)	Estimated from Cox P value and total number of deaths
	Protocol CE3005	radiotherapy+chemotherapy vs. radiotherapy	‐0.60	0.25	0.55 (0.25 to 1.20)*	Unadjusted HR from Cox regression
		radiotherapy+chemotherapy vs. radiotherapy	‐0.53	0.27	0.59 (0.27 to 1.32)	HR from Cox regression, adjusted for age.
Disease progression	Peters 2000	radiotherapy vs. radiotherapy+chemotherapy	0.70	NR	2.01	Cox HR, reported in paper
		radiotherapy+chemotherapy vs. radiotherapy	‐0.74	0.29	0.48 (0.27 to 0.84)	Estimated from Kaplan‐Meier plots*
		radiotherapy+chemotherapy vs. radiotherapy	‐0.74	0.25		Estimated from Cox P value and total number of deaths
	Protocol CE3005	radiotherapy+chemotherapy vs. radiotherapy	‐0.78	0.20	0.46 (0.21 to 0.99)*	Unadjusted HR from Cox regression
		radiotherapy+chemotherapy vs. radiotherapy	‐0.76	0.21	0.47 (0.21 to 1.03)	HR from Cox regression, adjusted for age.

* = used in primary meta‐analysis; NR = Not reported