| Study | Reason for exclusion |
|---|---|
| Argenta 2006 | Not an RCT. Included 21 women with stage IB‐IV. |
| Blohmer 2001 | The chemotherapeutic regimen of the intervention group did not include cisplatin. |
| Buxton 1990 | Retrospective study. |
| Chatterjee 2013 | RCT of 80 patients comparing adjuvant chemotherapy for stage IB to IIIB cervical carcinoma. The chemotherapy regimen of the intervention group consisted of cisplatin and 5‐FU. |
| Curtin 1996 | Not an RCT. |
| Dimpfl 1996 | Non‐randomised clinical trial. |
| Frigerio 1994 | Retrospective study. |
| Hansgen 2001 | Review. |
| Hansgen 2002 | Phase II study; included stage IIB patients in the analysis. |
| Harrand 2013 | Retrospective study. |
| Ikeda 1994 | Retrospective study. |
| Iwasaka 1998 | Included stage IIB patients in the analysis. |
| Kato 1994 | The chemotherapeutic regimen of the intervention group did not include cisplatin. |
| Kemnitz 1991 | The study included stage IIB patients in the analysis. |
| Killackey 1993 | Retrospective study. |
| Kim 2007 | Retrospective study. Included patients with stage IIB cervical cancer. |
| Koh 2000 | Review. |
| Lahousen 1990 | Non‐randomised study. |
| Lahousen 1999 | The control arm had received only chemotherapy as adjuvant treatment; the chemotherapeutic regimen of the intervention group did not include cisplatin; the study included stage IIB patients in the analysis. |
| Lai 1989 | Non‐randomised study. |
| Lai 1998 | More than 70% of patients were lost after randomisation. |
| Lai 1999 | Review. |
| Lee 2013 | Phase II study. |
| Lin 1998 | Retrospective study. |
| Lin 2000 | Retrospective study. |
| Linghu 2003 | Not an RCT. Study of neoadjuvant chemotherapy. |
| Liu 2014 | RCT of 564 patients with stage IB1 to IIA2 cervical carcinoma with high‐risk features comparing three groups: 1. Radiotherapy; 2. Radiotherapy with weekly cisplatin; 3. Paclitaxel and cisplatin every three weeks followed by radiochemotherapy with the same regimen. The authors did not report the number of patients allocated for each one of the three groups, doses of chemotherapy regimens, outcomes (DFS, OS or toxicity) for each group. No difference for DFS was found. |
| Lu 2000 | Review. |
| McCaffrey 2011 | Phase II study. |
| Morris 1999 | The study included stage IIB patients in the analysis. |
| Morton 1996 | Review. |
| Mossa 2003 | Retrospective study. Included patients with stage IIB cervical cancer. |
| MRC CE04/EORTC55954 | Study closed due to lack of accrual. Investigators did not reply our e‐mails. |
| Nakamura 2014 | Retrospective study. |
| Ng 1995 | Retrospective study. |
| Park 1997 | Review. |
| Park 2001 | Retrospective study. |
| Park 2012 | Retrospective study |
| Pu 2013 | RCT of 320 patients comparing two adjuvant chemotherapy regimens for stage IB to IIA cervical carcinoma. Included patients with high‐risk features. Control group consisted of single‐agent cisplatin and radiotherapy and the intervention group consisted of docetaxel, cisplatin and radiotherapy. |
| Richter 1982 | The chemotherapeutic regimen of the intervention group did not include cisplatin. |
| Rogers 2012 | A meta‐analysis of adjuvant radiotherapy and chemoradiation therapy after surgery for early cervical cancer that found only two trials that did not adressed the subject of chemotherapy. |
| Roth 1994 | Review. |
| Rushdan 2004 | Phase II study. |
| Russel 1995 | Non‐randomised study. |
| Ryu 2005 | Retrospective study. |
| Schwarz 2011 | Phase I‐II study. |
| Sehouli 2012 | An open‐label RCT of 271 patients comparing two adjuvant chemotherapy regimens for stage IB to IIB cervical carcinoma. Included patients with high‐risk features. Control group consisted of single‐agent cisplatin and radiotherapy and the intervention group consisted of paclitaxel, carboplatin and radiotherapy. |
| Shimizu 1995 | Review. |
| Shu 2015 | Phase I study of one cycle of cisplatin and paclitaxel before, two cycles concurrent with intensity‐modulated radiotherapy (IMRT) and one cycle after IMRT as adjuvant treatment to stage IB‐IIA cervical cancer with high‐risk factors in women that underwent radical hysterectomy and pelvic lymphadenectomy. |
| Sivanesaratnam 1987 | Retrospective study. |
| Sivanesaratnam 1989 | Retrospective study. |
| Sivanesaratnam 1998 | Retrospective study. |
| Strauss 2002 | Phase II study. |
| Wada 1995 | Retrospective study. |
| Wang 2015 | Phase II study. |
| Watanabe 2006 | Phase I study. |
| Wen 2013 | Retrospective study. Included patients with stage IIB cervical cancer. |
| Wertheim 1985 | Retrospective study. |
| Wolfson 2012 | Description of an appropriateness criteria to adjuvant radiotherapy in stage I and II cervical carcinoma. |
| Yamamoto 2004 | The study included stage IIB patients in the analysis; the chemotherapeutic regimen of the intervention group did not include cisplatin. |
| Yessaian 2004 | Retrospective study. |
| Yoon 2014 | Retrospective study. Included patients with advanced stage disease. |
| Zanetta 1995 | Non‐randomised study. |
| Zhang 2012 | Retrospective study. Included patients with stage IIB cervical cancer. |
| Zola 2003 | RCT that randomised 199 women after radical hysterectomy and pelvic lymphadenectomy to receive EBRT or platinum‐based chemotherapy. After 3 years there was no difference in survival between the two treatment groups. |
DFS: disease‐free survival EBRT: External beam pelvic radiotherapy OS: overall survival RCT: randomised controlled trial