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. 2019 Apr 12;10:380. doi: 10.3389/fphar.2019.00380

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Copyright © 2019 Marafini, Di Fusco, Dinallo, Franzè, Stolfi, Sica, Monteleone and Monteleone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AhR antagonist abrogates the effect of NPD-0414-2 and NPD-0414-24 on IFN-γ and IL-22 expression in lamina propria mononuclear cells (LPMC) of inflammatory bowel disease (IBD) patients. (A,B) IBD LPMC were stimulated in vitro with anti-CD3/CD28 beads and 1 hour later were treated with NPD-0414-2, NPD-0414-24 (final concentration 200 nmol) or Ficz with or without the AhR antagonist (A-AhR, final concentration 10 μmol). After 18 h, IFN-γ and IL-22 RNA transcripts were analyzed by real time-PCR. Histograms are representative of 5 separate experiments; values are expressed as mean ± SEM (*Fics vs AhR antagonist p < 0.05, ** NPD-0414-2 vs AhR antagonist p < 0.03, *** NPD-0414-24 vs AhR antagonist p < 0.01).