. 2019 Apr 12;10:753. doi: 10.3389/fimmu.2019.00753

Table 1.

Lymphocyte phenotyping.

	Patient I		Patient II.A		Patient II.B
Age (years)	9		14		19
CD4⁺ T cells		Ref. Range		Ref. Range		Ref. Range
CD4⁺ cells/microliter	590	650–1,500	340	530–1,300	284	530–1,300
CD4⁺CD45RA⁺ naïve T cells (%)	33	46–77	39	33–66	27	33–66
CD4⁺CD45RO⁺ memory T cells (%)	60	13–30	59	18–38	72	18–38
CD4⁺HLA-DR⁺ activated T cells (%)	21	3–13
CD8⁺ T Cells
CD8⁺ cells/microliter	1,728	370–1,000	175	330–920	518	330–920
CD8⁺CD45RA⁺ naïve T cells (%)	65	63–92	66	61–91	54	61–91
CD8⁺CD45RO⁺ memory T cells (%)	24	4–21	29	4–23	35	4–23
CD8⁺HLA-DR⁺ activated T cells (%)	17	6–29
B Cells
CD19⁺ cells/microliter	69	300–600	410	200–600	136	100–600
CD27⁺ memory B cells (%)	6	18.6–46.7	3.3	13.3–47.9	1.5	17.5–46.5
CD38⁺IgM⁺ transitional B cells (%)	74	4.6–8.3
CD21^low immature B cells (%)	12.3	5.9–25.8	58.5	2.9–13.2	15.4	3.2–19.6
Immunoglobulins
IgM (mg/dL)	1,230	53–334	199	40–140	320	44–277
Total IgG (mg/dL)	486	613–1,295	1,550	650–1,500	1,410	726–1,521
IgA (mg/dL)	9	69–309	143	60–310	214	87–426

Values outside of the reference range are in bold. Reference range values are from Shearer et al. (19) for T cells and Piatosa et al. (20) for B cells.