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. 2019 Apr 12;10:311. doi: 10.3389/fgene.2019.00311

Figure 6.

Figure 6

MtDNA damage in different mutant strains relative to young wild type N2 animals as measured using S-XL-qRT-PCR DNA damage assay. Relative to wild type animals, mpst-1, sod-2/-3, and daf-2 mutant strains had 3.4-, 2.7-, and 4.0-fold higher mtDNA damage, respectively (p < 0.01 for both mpst-1 and sod-2/-3 mutants and p < 0.0001 for daf-2 mutant, Student’s t-test). mev-1 mutant C. elegans strain had no significant difference in mtDNA damage level compared to wild type N2 C. elegans (p > 0.05, Student’s t-test), n = minimum 3 independent experiments.