Table 1.
Baseline characteristics of 191 untreated chronic lymphocytic leukemia patients
| Parameter | No. of cases (%) | AFR (mean±SD) | p-value |
|---|---|---|---|
| Age (yr) | |||
| > 65 | 66 (34.6) | 15.01±5.20 | < 0.001 |
| ≤ 65 | 125 (65.4) | 18.86±7.82 | |
| Sex | |||
| Male | 128 (67.0) | 17.22±6.04 | 0.399 |
| Female | 63 (33.0) | 18.16±9.25 | |
| Binet stage | |||
| A | 76 (39.8) | 17.46±5.55 | 0.913 |
| B or C | 115 (60.2) | 17.58±8.21 | |
| CD38 (> 30%) | |||
| Positive | 41 (21.5) | 17.93±5.47 | 0.692 |
| Negative | 150 (78.5) | 17.42±7.68 | |
| ZAP-70 (> 20%) | |||
| Positive | 86 (45.0) | 17.87±5.49 | 0.555 |
| Negative | 105 (55.0) | 17.25±8.44 | |
| β2-MG (mg/L) | |||
| > 3.5 | 82 (42.9) | 16.40±6.17 | 0.061 |
| ≤ 3.5 | 109 (57.1) | 18.38±7.89 | |
| TP53 disruption | |||
| Yes | 43 (22.5) | 15.74±5.14 | 0.066 |
| No | 148 (77.5) | 18.05±7.69 | |
| IGHV mutation | |||
| Yes | 114 (59.7) | 16.84±5.54 | 0.112 |
| No | 77 (40.3) | 18.54±9.17 |
AFR, albumin-to-fibrinogen ratio; SD, standard deviation; β2-MG, β2-microglobulin; TP53, tumor protein 53; IGHV, immunoglobulin heavy variable-region.